Tsuboi, S. A new synthesis of piperine and isochavicine. Kaga, H. New access to conjugated dien- and enamides.
Synthesis of dehydropipernonaline, pipernonaline and related biologically active amides. Synlett , , 8 , Schulze, A. New approaches of aldol-type reactions demonstrated by simple syntheses of piperine. Naskar, D. Rogoski, J. Schobert, R. Koul, S. Chatterjee, A. Singh, J. Loder, J. Okogun, J. Banerji, A.
Ivan, A. Okwute, S. Vasavirama, K. Correa, E. Nargotra, A. Kulshreshta, V. Singh, N. Studies on the analeptic activity of some Piper longum alkaloids. Micevych, P. Franco-Cereceda, A. Calcitonin gene-related peptide CGRP in capsaicin-sensitive substance P-immunoreactive sensory neurons in animals and man: distribution and release by capsaicin.
Peptides , , 8 2 , Lundberg, J. Co-existence of substance P and calcitonin gene-related peptide-like immunoreactivities in sensory nerves in relation to cardiovascular and bronchoconstrictor effects of capsaicin. Saria, A. Release of substance P- and substance K-like immunoreactivities from the isolated perfused guinea-pig lung.
Use of immunoblockade to study the involvement of peptidergic afferent nerves in the intestinal vasodilatory response to capsaicin in the dog. Theodorsson-Norheim, E. Capsaicin treatment decreases tissue levels of neurokinin A-like immunoreactivity in the guinea pig.
Acta Physiol. Miyauchi, T. Szallasi, A. Kawada, T. Mujumdar, A. Atal, C. Eun, J. Wattanathorn, J. Pei, Y. Liu, G. Webb, G. Naidu, K. Pistolesim, E. Rauscher, F. Khajuria, A. Takaki, M. Cole, O. Pharmacological studies of piperine; I. Effects of piperine on transmural nerve stimulation. Annamalai, A. Johri, R. Bhardwaj, R. Khamar, B. Hiwale, A. Shah, S. Tang, X. Singh, A. Balakrishan, V. Velpandian, T. Gupta, S. Rosenberg Zand, R.
Majeed, M. Reen, R. Badmaev, V. Shin, K. Sharma, A. Bae, G. Sharma, S. Bang, J. Tasleem, F. Sabinaa, E. Li, S. Khan, I. Begum, N. Park, B. Dhuley, J. Durgaprasad, S. Peela, J. Vijayakumar, R. Malini, T. Goldstein, D. The effects of drugs on membrane fluidity. Jhanwar, B. Diwan, V. Veerareddy, P. Shailajan, S. Vyas, A. Gupta, V. Sarkar, B. Patel, S. Rode, S. Rout, K. Jain, T. Kamal, Y. Johnson, J. Soumyanath, A. Thuillier, P. Dogra, R. Han, Y. Khandelwal, S. Karan, R. Effect of Trikatu Piperine on the pharmacokinetic profile of isoniazid in rabbits.
Dama, M. Effect of trikatu pretreatment on the pharmacokinetics of pefloxacin administered orally in mountain Gaddi goats. Studies on Piper chaba as a bioavailable agents.
IDrugs , , 17 , Singh, M. Alteration of pharmacokinetics of oxytetracycline following oral administration of Piper longum in hens. Janakiraman, K. Studies on effect of piperine on oral bioavailability of ampicillin and norfloxacin.
Medicines , , 5 3 , Kasibhatta, R. Influence of piperine on the pharmacokinetics of nevirapine under fasting conditions: a randomised, crossover, placebo-controlled study. Drugs R D. In Vivo assessment of enhanced bioavailability of metronidazole with piperine in rabbits. Pooja, S. Analgesic activity of Piper nigrum extract per se and its interaction with diclofenac sodium and pentazocine in albino mice. Pharmacol , , 5 1 , Influence of piperine on nimesulide induced antinociception.
CO;2-S ]. Bano, G. The effect of piperine on pharmacokinetics of phenytoin in healthy volunteers. Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers.
Pattanaik, S. Pharmacokinetic interaction of single dose of piperine with steady-state carbamazepine in epilepsy patients. Kapil, A. Piperine: a potent inhibitor of Leishmania donovani promastigotes in vitro. Lee, S. Inhibition of aflatoxin B1 biosynthesis by piperlongumine isolated from Piper longum L.
Kirk, K. Acta , , 2 , Madhyastha, M. Aspergillus parasiticus growth and aflatoxin production on black and white pepper and the inhibitory action of their chemical constituents. Bhutani, M. Anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes.
Piperine from the fruits of Piper longum with inhibitory effect on monoamine oxidase and antidepressant-like activity. Tokyo , , 53 7 , Selvendiran, K. Cytoprotective effect of piperine against benzo[a]pyrene induced lung cancer with reference to lipid peroxidation and antioxidant system in Swiss albino mice. Fitoterapia , , 74 , Muhtaseb, M. Oreilly, D. Free radical activity and lipid soluble anti-oxidant vitamin status in patients with long-termileal pouch-anal anastomosis.
Colorectal Dis. Manoharan, S. Chemopreventive efficacy of curcumin and piperine during 7,dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Singapore Med. Chemopreventive effect of piperine on modulating lipid peroxidation and membrane bound enzymes in benzo a pyrene induced lung carcinogenesis. Nirala, S. Influence of alpha-tocopherol, propolis and piperine on therapeutic potential of tiferron against beryllium induced toxic manifestations.
Ibrahim, M. Hepatoprotective activity of Sapindus mukorossi and Rheum emodi extracts: in vitro and in vivo studies. World J. And while most people think of it as nothing but a seasoning, black pepper can benefit health as well. Both turmeric and black pepper have key active ingredients that contribute to their anti-inflammatory, antioxidant and disease-fighting qualities.
The key compounds in turmeric are called curcuminoids. Curcumin itself is the most active ingredient and appears to be the most important. As a polyphenol, curcumin has several advantages to health.
Black pepper contains the bioactive compound piperine, which is an alkaloid like capsaicin, the active component found in chili powder and cayenne pepper 3. Piperine has been shown to help relieve nausea, headaches and poor digestion and also has anti-inflammatory properties 4 , 5 , 6. Still, its most significant benefit may be its ability to boost the absorption of curcumin 2 , 7. Curcumin in turmeric and piperine in black pepper have been shown to improve health due to their anti-inflammatory, antioxidant and disease-fighting qualities.
Unfortunately, the curcumin in turmeric is poorly absorbed into the bloodstream. As a result, you could be missing out on its advantages to health. However, adding black pepper can help. One study showed that adding 20 mg of piperine to 2 grams of curcumin increased its absorption significantly 8.
First, piperine makes it easier for curcumin to pass through the intestinal wall and into your bloodstream 9. Second, it may slow down the breakdown of curcumin by the liver, increasing its blood levels. The piperine found in black pepper enhances curcumin absorption, making it more readily available to be used by your body.
Studies also demonstrate that turmeric may play a role in preventing and treating arthritis, a disease characterized by joint inflammation and pain 15 , 16 , Piperine has been shown to have anti-inflammatory and anti-arthritic properties as well.
Int Immunopharmacol. Arch Pharm Res. Vijayakumar RS, Nalini N: Piperine, an active principle from Piper nigrum , modulates hormonal and apo lipoprotein profiles in hyperlipidemic rats. J Basic Clin Physiol Pharmacol. Mol Cell Biochem. Scholz S, Williamson G: Interactions affecting the bioavailability of dietary polyphenols in vivo. Int J Vitam Nutr Res.
Kasibhatta R, Naidu MU: Influence of piperine on the pharmacokinetics of nevirapine under fasting conditions: a randomised, crossover, placebo-controlled study. Drugs R D. Badmaev V, Majeed M, Prakash L: Piperine derived from black pepper increases the plasma levels of coenzyme Q10 following oral supplementation. J Nutr Biochem. Download references.
You can also search for this author in PubMed Google Scholar. KSK and DHH participated in the data analysis and the design of the study, and drafted the manuscript. All authors read and approved the final manuscript. Reprints and Permissions. Bang, J. Arthritis Res Ther 11, R49 Download citation. Received : 30 December Revised : 04 March Accepted : 30 March Published : 30 March Anyone you share the following link with will be able to read this content:.
Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative.
Skip to main content. Search all BMC articles Search. Download PDF. Abstract Introduction The objective of this study was to determine the anti-inflammatory, nociceptive, and antiarthritic effects of piperine, the active phenolic component in black pepper extract. Conclusions These results suggest that piperine has anti-inflammatory, antinociceptive, and antiarthritic effects in an arthritis animal model. Introduction Rheumatoid arthritis is characterized by chronic proliferative synovitis, inflammatory immune cell infiltration into the synovial fluid and cartilage destruction [ 1 ].
Materials and methods Cell culture and reagents All in vitro experiments were carried out with fibroblast-like synoviocytes derived from patients with rheumatoid arthritis RA. Western blot analysis FLSs cultured 2. Histological assessment of inflammation The rats were killed after 9 days of carrageenan and control treatments.
Rat models of paw hyperalgesia and arthritis Sprague-Dawley 5-week-old to 6-week-old male rats, purchased from SLC Shizuoka, Japan , were used in this study. Figure 1. Full size image. Figure 2. Figure 3. Figure 4. Figure 5. Discussion Anti-inflammatory drugs used for treating chronic inflammatory diseases such as rheumatoid arthritis are typically prescribed long term to properly control the disordered immune system.
References 1. Article PubMed Google Scholar 2. The blots were developed using the ECL method Amersham. The rats were killed after 9 days of carrageenan and control treatments. Immunohistochemical staining was performed to determine the degree of immune cells infiltration into the joints. The degree of inflammation was evaluated on a scale from 0 to 5 by three different pathologists that had been blinded to the treatments.
They were adapted for at least 1 week prior to the start of the experiment. All subjects were habituated to the behavioral test chambers and handled with special care to minimize stress. A total of 10 rats were studied per group and the test was performed blind. Piperine dissolved in corn oil was fed orally 1 h before carrageenan injection. To evaluate paw hyperalgesia, we measured the tolerance to increasing mild pressure on the affected paw between a flat surface and a blunt pointer of the instrument, as manufacturer's protocols.
The carrageenan-induced arthritic rat model was prepared as described previously [ 15 ]. To evaluate the arthritic progression of carrageenan-induced arthritis in the rat, three different parameters were measured: paw volume, squeaking score in the ankle flexion test, and weight distribution ratio WDR. These were considered behavioral indicators of carrageenan-induced arthritis and checked daily for 9 days. With progression of arthritis, redness and swelling of the ankle joints and arthritic pain started to appear and reached a maximum on day 1 after the carrageenan injection.
At that time, piperine and prednisolone dissolved in corn oil was administrated orally once a day for 8 days. Paw volumes were expressed as relative values to that of day 0 when carrageenen was injected. The ankle flexion test involved gentle flexion and extension of the carrageenan-injected ipsilateral hind limb, as described by Kwon et al.
This elicited vocalizations squeaking that were scored on a scale squeaking score as a measure of hyperalgesia. The procedure of flexion and extension were repeated 10 times in every 5 s and the rating of 0 null or 1 vocalization was given to each hind limb.
This test was performed only once a day in each animal. To evaluate arthritic pain, the rat was placed in the test box of an incapacitance meter in which a slanted plank is located. The bearing force of each hind limb was quantified by two mechanotransducers, separately placed below the two hind limbs: one is normal and the other is the arthritic limb.
The bearing force of each hind limb was estimated as a 5-s average, and the mean bearing force was calculated from four separate estimations. As the pain and swelling of the ankle progressed due to induction of arthritis, the balance of weight was disrupted, resulting in a reduction of the WDR in the arthritic leg.
All behavioral tests were performed blinded. Effect of piperine on the production of proinflammatory mediators. Experiments were performed with synovial cells derived from patients with rheumatoid arthritis. Next, we tested whether piperine inhibited the expression of the extracellular matrix degradation enzymes MMPs.
Effect of piperine on the production of extracelluar matrix degradation enzymes matrix metalloproteinases MMPs. Effects of piperine on signaling pathways and transnuclear migration. Because piperine significantly inhibited the production of PGE 2 and the protein levels of COX-2, we tested whether piperine had antinociceptive effects in a rat model of carrageenan-induced paw hyperalgesia. Analgesic and antiarthritic effects of piperine in rat models of paw edema and arthritic ankle.
The y axis indicated the pressure g that was tolerated before the rat exhibited signs of pain. The results indicated that piperine had antiarthritic effects. To demonstrate the in vivo antiarthritic effect of piperine, the efficacy of piperine was tested in a rat model of carrageenan-induced arthritis. The degree of inflammation in five specimens was evaluated by three different pathologists. Histological evaluation of the anti-inflammatory effects of piperine.
Anti-inflammatory drugs used for treating chronic inflammatory diseases such as rheumatoid arthritis are typically prescribed long term to properly control the disordered immune system.
Thus, there is a strong need to develop safe and effective drugs for the long-term use. Many groups have studied non-steroidal anti-inflammatory small molecules that were derived from natural sources with the aim of developing new treatments for clinical use [ 17 ]. For example, curcumin is a polyphenolic compound derived from the dietary spice, turmeric.
Recently, curcumin has been shown to possess diverse pharmacological properties, including anti-inflammation, antiproliferation, and antiangiogenesis. Currently, curcumin is in phase I of clinical trials [ 18 ]. Piperine is also a promising natural source with potential for clinical use. Piper longum Linn. Therefore, piperine has been proven effective indirectly, but its mechanism of action remains unknown.
0コメント